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Additional Affiliations

Associate Professor, Division of Cardiology, Department of Medicine, Faculty of Medicine, UBC
Scientific Director, B.C. Centre for Improved Cardiovascular Health
UBC-Heart and Stroke Foundation Professor in Women’s Cardiovascular Health

Research Interests
  • Outcomes after coronary revascularization (PCI, CABG)
  • Sex differences in diagnosis, treatment, and outcomes of patients with coronary disease
  • Health services research—evidence-based medication use post-AMI
  • Cardiovascular epidemiology

After completing undergraduate work in biochemistry and kinesiology, followed by a master’s degree in Experimental Pathology, Dr. Karin Humphries completed her doctoral degree in Epidemiology and Health Services Research at Erasmus University in the Netherlands.

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Her current work is mostly focused on sex and gender differences in the diagnosis, treatment, and outcomes in subjects with coronary artery disease. A co-investigator with the GENESIS Team funded under an ICE grant from the Canadian Institutes of Health Research, Dr. Humphries is currently investigating sex and gender differences in the presentation of patients with chest pain, but angiographically normal coronaries.

She is the inaugural Scientific Director of the B.C. Centre for Improved Cardiovascular Health (ICVHealth). In this role, she is committed to improving health outcomes for British Columbians at risk for, or living with, cardiovascular disease by generating and applying new evidence to improve the delivery of cardiovascular care in the province.

Together, Dr. Humphries and ICVHealth have undertaken multiple projects that demonstrate potential for broad impact by improving patient outcomes and enhancing resource utilization. The FREEDOM Real World study aims to assess the effect of the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multi-Vessel Disease (FREEDOM) trial on clinical practice in B.C. Another project, the Fractional Flow Reserve (FFR) Select Trial, will determine whether FFR, a unique method for quantifying the magnitude of coronary flow obstruction, should be used systematically for all potential coronary lesions, or selectively, as determined by the attending physician.

Additional work includes evaluation of outcomes of patients after percutaneous coronary intervention (PCI) and the impact of a relative increase in PCI compared to coronary artery bypass surgery, which has been observed across Canada. Most of this work is done using clinical data from the B.C. Cardiac Registry, linked to Ministry of Health administrative databases (DAD, MSP, PharmaNet) and Vital Statistics.

Health research in the heart of Vancouver